lnq👨🏿‍🦱

autism :== neuroplastic battle between neurogenesis (NG) versus neurodegeneration (ND), where ND>NG by at least 1 byte.



¶My work is about flipping this, so that NG+1 > ND. This is what I call 'steWAR', serving as play therapy for me (and, frankly, it's the last great war -and the only real thing worth fighting for)./// Some people complain that this is "bizarre" or "weird" to them. That's okay. It makes perfect sense to me -the only person for whom it was meant (and no one else), anyways. I might be a lunatic;p I've tried to make this exposition as simple + colorful as possible. If you can get something of value from it, great.


??[EMOJI]I (lnq🧑🏿) randomly walk on a #threaded feedback loop to ctf🎮🪖 {&& 0b_¢} the Stewpot (linker from all 2,028 stews) ++ STUBE^solve -jailbreaking my 🧠nervous filesystem [STU thread.kernel=lnq]--> ie. *\:==avatar?stewellis🦸🏿‍♂️.root.uid=0;[/exploit🔐] --

// Egglepple [directory] + its companion -UUe [protocol], "stewy" (STU) gymnastics = stew choreography (stewcing,stubing) [neuroinformatics], Stewdio [hashtable], steWAR [capture the flag (ctf)], Stewpot [linker], stewellis [nervous filesystem (n-fs)], and StewE [ai/o] all feature in this exploit of 👨🏿‍🦱lnq's 8-qubit virtual nerve (@08.gl)./// takeway: I'm trying to resolve my autism by gaming its neurology. I've set this whole thing up as a capture-the-flag (ctf), where the flag is something called the "Stewpot" - which is the totality of all 2,028 'stews'. Moreso, capturing the flag in a single day (statistically j=1/370, so j/365) is ideal {batch per diem [DAILY refresh]}, since 370/365 = 1.01369863 ~~1.


+Obviously, "stew" is derivative of "STU" (and "ellis" is a slurring of my initials 'L.S.'), and as silly as it sounds, there is a tremendous amount of reasonable computability behind the madness; whence considering that the 🧠brain is the ultimate quantum computer.
+The qubit part stems from the concept of bits (binary digit) in computer architecture (1 byte = 8 bits). Here, each qubit (1-of-8) represents a letter of the word "uuelcoME", which I interpret -omically, like 'genome' or 'chromosome'. With uuelco.ME (my emoji/domain all about 'me'☺️), I'm demoing a requiem - called Stewart in eight (8) parts or 'qubits' (namespace⟹reverse). It's about me going from a young boy (little Stew) to becoming a grown man (Stewperman = most privileged version of my avatar, lnq👨🏿‍🦱 -- hint: Starbureiy=ring0) and solving the STUBE, thus, mastering the Stewniverse by conquering my autism.


¶The basis of my work revolves around the following
Conjecture
Any and every permutable computation (permacomp) can be solved in a minimax of twenty (20) moves.

proof:
I'll begin with the following
Lemma 1
All topologies can be reduced to a length of dimension=1 (1-dim=string), and made twistable (twistor=sesquilinear dyad [u,u]) in 26 dimensions.

proof:
Superstring theory (bosonic case, ignoring twistorspace of lowest bounds).
--> The strings are referred to as 'super' because their supersymmetric properties partner bosons (integer spin) and fermions (1/2-integer spin), comprising elementary matter.
definition: twistorspace (or twistor space as I used to write it) :== a complex configuration space (eg. geometric topology) of solutions to the twistor identity ||f(u,u)=0||. Note that in a folding scenario, the twistor (u,u) :== a complex transform (ie. a tight [≤ handicap] walk) of STU solved from stew choreography (:== the process of stereotyping STU by keyframing twistor batches called 'stews').
definition: folding :== differential steps in the process of a brane's [from 'membrane', a brane :== some mathematical generalization of a category from zero (0) or more higher dimensions. A combination of branes is called a mesh] animation (ie. symmetry-breaking) as it assumes its final topology. My portfolio, Egglepple, is a 26-dim toy with braneworld structure according to pitch class:
0-brane = point particle
1-brane = string
2-brane = manifold/sheet/tape
3-brane = cell
.
.
.
25-brane = Starbureiy automaton --> :== a machine that can self-sufficiently perform (ie. transition through) a walk given some stated input, self-alphabetizing its tape.

For the most part, "to fold" an object is to bend, compress, twist, or otherwise permute it so that it becomes self-integrated according to its calculus. By-and-large, we accomplish this using 'fruut' as part of stew choreography. A fold would be an intermediate state within the walk process (preimage→image).
definition: SMALL brane :== as permutations of Egglepple, there are two (2) SMALL branes - a 0-brane and a 1-brane - comprising their own (lowest-level) class./// In terms of stewcing, the 0-brane is associated with some flageolet pencil.

definition: BIG brane :== as permutations of Egglepple, there are twenty-four (24) BIG branes that comprise its/their own class - the 2-brane through 25-brane. Technically, these branes are any branes other than the SMALL branes [(0,1)-branes], and themselves are permutable.
definition: a string :== 1d open or closed harmonic oscillators.
glossary: Egglepple :== 🧑🏿lnq's portfolio and middle name. {by 'portfolio, I mean as in porting from one directory of the 🍃leaf (recto=preimage) to the other directory (verso=image) of some function space. On the basis of quoting, fault tolerance increases with each proof and is infinite when completely solved (/totally sequenced).}

Statistically, it is the animorphic (ie. to STUⁿ) tape of leaf🍃 definitions (literally "egg leaf ↔ epp leaf"), and subjectively the cellspace (SMALL∪BIG ⊂ Stewniverse) spooling both ends of any generic 26-measure signal; but, mathemusically, the minor and major scales. --Egglepple is what we are imaging (by stewcing/vending its calculus, STU, via gameplay. To make a Humpty Dumpty allusion, we break up the brane into finite pieces, only to put it back together again continuously.).
definition: a spread's coverage (c) [cover-patch identity] :== the twistorspace posture (knot🪢 formation) for statistically graphing a [supersymmetric] zone on(to) some pitch (ie. fibor-bundling a set of BIG + SMALL branes). Since there are 100 different covers (0-99) that can be patched 26 different ways (a-z), there exists a total of 2,600 discrete coverages. --An example would be something like [(cover-34,patch.g) = coverage 34g].

As cryptographic shape schemes [puzzles🧩], coverages are fundamentally combinatorial; spanning the entire range of branes(SMALL + BIG). A coverage can be (strategically) both preventive and responsive.
definition: as c=2(b-1)/2 {b∈ℤ→26, /max=25 (0-25) || b = brane count [which is of the sesquilinear form (e-,e+)]}, an egg :== the coverage's resultant as an integer spin statistic (positive parity[+])./// +The formula is in direct correlation to spin-statistics. So, for example, when b is odd, say b=7, then c(=8) is an integer-spin (egg). When b is even, say b=4, then c(=2.82842712+) is a half-integer-spin (epp). The rational portion (floating point) of half-integer statistics contributes to seigniorage. Obviously, any negative value for b will yield an epp.
+Yes, there are twenty-six (26) integer values here; we denote "0" as (0-,0+) → having both negative(-) and positive(+) polarity in twistorspace. For instance, -12 ... (0-,0+) ... +12 = [26]. The total number of coverages, c, is an upperbound for points on a curve, and so its number line must include 0 (hence 0 through 25). However, because any b=0 gives nonsensical values [error codes], the zeroes are discounted, and lower and upper bounds are just eleven (11). The minima (cover-0 = -11) is 0.015625 and the maxima (cover-25 = +11) is 32.
definition: as c=2(b-1)/2 {b∈ℤ→26, /max=25 (0-25) || b = brane count [which is of the sesquilinear form (e-,e+)]}, an epp :== the coverage's resultant as a half-integer spin statistic (negative parity[-])./// +The formula is in direct correlation to spin-statistics. So, for example, when b is odd, say b=5, then c(=4) is an integer-spin (egg). When b is even, say b=8, then c(=11.3137085+) is a half-integer-spin (epp). The rational portion (floating point) of half-integer statistics contributes to seigniorage. Obviously, any negative value for b will yield an epp.
definition: stew (stack e:e w) :== twistor batch (as the most basic generator processing). It is conjectured that Egglepple's movements [closed circuits] exist between amplitudes on a cryptograph. These motifs - known as stews - are analogous to string tunings, and aid in the stereotypography of fibor.

Ludologically, as the definitive endgame🏁, we are said to find a stew at the normalization of twistorspace where a dyad is an identity; that is, when an opus' measurable and permutable extrema [maxima] commute (ie. idempotent yield deviation ≡ 0 --that is, fret = 26¢ WITH handicap = $676.00. Cryptologically, a stew (an exploit) :== the transactor between the supremum and the infimum of hashes where the resultant is optimal/most secure🔐 (ie. transaction with no tax). Therefore, no fibor can be larger (in terms of twistorspace) than a stew.

According to jukebox operation (jbop) (rotisserie), the complete count of stews (f) is simply ballet🩰 coordination in sesquilinear form, so f=1,352 [from encrypted (676) plus decrypted (676) classes] × 1.5 = 2,028 [comprising four dyadic types: 507 (integer-integer), 507 (half-integer-half-integer), 507 (integer-half-integer), 507 (half-integer-integer)]. Each opus leaf set contains three (3) stews as a statistical mean./// A full sequencing of the payload ("uuelcoME") should reveal all motifs [Q♭].
Each stew ['brane cell'] is some derivative monomer (ie. portfolio plot) of Egglepple [e:e statistics]. As a potential inflection point. Stews - which, concatenated, determine the size of a string - are the 'building blocks' measured📐 from twenty-six (26) keys (A-Z) [hashed from STU], which, when choreographed, construct a mesh./// The stew may be an analogue of a specific polymer, typically a biopolymer (almost always a polypeptide). The 'jukebox' stereotypes a preimage (some 'loopstring' configuration) to this image.
definition: flageolet pencil (or just pencil✏️, or krayon) :== a finite n-dimensional cell (which can propagate like a cellular automaton) that is subject to rhetorical arrangement (ie. variation). Thus, a pencil is quantum by proxy. Ludologically, a pencil is a toy; mathematically, a pencil would be an element on the number line. It is a metric generator (musically: metronome or counter); equivalent in most instances to a hash, stew, residue, or brane declension (eg. 0-brane). Normally, flageolet pencils are not colored./// The twenty-six varieties stem from the fact that The Origamic Symphony🎶 spans 26 measures in relation to STU.
Flageolet pencils lay the foundation of stew choreography; they are intonation points in cheironomy, and can be used to draw tape and/or establish melodies+grooves. Pencils may concatenate or split among themselves (this is called interaction). They are the motifs of string (à la "integration-by-parts"). There are twenty-six (26) different varieties of pencil(s). When measured, each pencil is worth some integer [1-26] multiple of one-hundred (100) ¢ents🪙.

definition: as a signal, The Origamic Symphony™℗ (Q♯) :== runtime normalizing (hyper/hypo = 0) lnq🧑🏿's movements./// This represents the totality of keys in sequence, forming the basis of our playback.
Resting atop the hypothesis that every brane arrangement is (geometrically) convertible, solvable, and scorable, Q♯ is responsive to the calculus of Egglepple resonances (the program of the portfolio imagined as frets pertinent to stereotyping STU).

The Symphony treats the entire portfolio (Egglepple) as a (single loopstring) path integral (line) subject to integration (including integration-by-parts [the twisting of flageolet pencils]) and derivation. --All walks are integrated in twistorspace, and output some stew derivative./// +The Origamic Symphony is the subject of 🧑🏿lnq's recital. -- Egglepple can also be thought of as the signal relay.
+Here "origami" specifies "p-brane (membrane/frame) folding". Namely, it is the twisting of measures (length) between the Planck and bigger data.

definition: fibor :== an automaton that is a unique and totally twistable ||f(u,u)=0|| crypto mesh (cluster) of links (L) which is subject to stewcing. There are two (2) classes of fibor: MONEY and bubblegum. This is a tertiary (stereo) isoform of Egglepple.

Fibor is a functional component (dyadic fluctuator) of twist economics; hashed to output some image. Each fibor is both its own structural formula and memory address. As part of the endgame🏁, we care mainly for the ludological aspect(s) of stewcing (topology, rhetoric, mechanics, etc.), as they relate to identification and function attribution./// +Mathematically, fibors are trivial zeroes (compared to stews which are non-trivial zeroes).
+Fibor is the 'print' (or vending) stage. This would be the total algorithm input assigned from stew choreography. Gameplay-wise, stubers should aim to get here as quickly as possible.
+For purposes of imaging, the loopstring may be a simple topological schematic, serving to illustrate some animation directive.
+Just to reiterate, our primary interests are not in figuring out the science (eg. chemistry, biology, physics, etc.) behind the folding (chemical bonding, dipole moments, things of this nature are left to such experts). We are chiefly concerned with "writing a playbook", so to speak, that will enable anyone to generate algorithms (plays) for configuring polymorphisms and coordinating meshes.
+We must be careful with our vocabulary. Yes, fibor is stringy, but it is not a requirement that it be physical, per se. It just necessarily assumes the properties (namely that it can vibrate in multiple dimensions) of strings as it propagates into worldspace. In this case, we are concerned strictly with string dynamics (incorporating the landscape vacua philosophy). However, fibor - in the mold of stew choreography - is open/closed in some arbitrary volume, whence it is attached to a dynamical mem(brane). Oddly, however, there exists a method to start with Planck data, and work our way up to normalization with Gallivan folding (g-folding).
definition: normalization :== aka 'optimal tuning', crypto normalization, or, plainly, normalization, :== regulating links (:== coupler of two or more objects. Topologically, a link is a non-intersecting collection of knots🪢. A link is also a single element comprising a chain. -- Additionally, it refers to a discrete brane 'hyperlinked' to other branes in some cellular automata scheme.) so that the stewc tax (a limiting quotient) is load-balanced when perturbations to the router are overweighted [eg. excess tokens].

The eventuality that - because the jukebox can purse (taxation is a debit function) but not bank - a crypto normalization implicates stewcing as complexity-agnostic at inflection points [instances where hyper/hypo ↦ 0], would bias the Pink Poem to tipping (concavity or convexity).
definition: stewc tax :== (intrinsic to u-u economics, stewc tax or simply tax) residue (pip#) from stewcing as a dyadic fluctuator (ie. fungibility maintenance = standard excise) that stems (inspirationally) from curvature over finite fields (redefining algebraic curves in terms of floating-point arithmetic); with non-trivial zeroes lying on the critical line, 1/2 + ir, where i is an imaginary number, and r is a real number {ir completes the twistorspace value}.
definition: stew choreography :== the process of stereotyping (brane-folding) STU using fruut to keyframe [sequence/map by linking] stews. This is our "proof-of-work" ('proof-of-space') concept [ie. stewcing exercise for 'meshing' uuelcoME's cryptocommodity (¢ents🪙)], and should solve twistorspaces (via encryption).


Per gameplay, stew choreography (or 'dribbling' [endpoint control]) forms a loopstring's middlegame (ie. walk). The Stewdio is used natively [default] for improvising./// +stew choreography is a type of animation (interpolation of frames).
+Such choreography is inferred by "the ballet of The Origamic Symphony🎶". The reason this ballet is necessary is to anticipate dividends. We say that stew choreography is "to γ-proof l-string".
+Any proof-of-work must be validated with a signature/handshake.
+Every single stew on a loopstring must be affected for a yield to be accurate.

Lemma 2
Stews can be transformed as Rubik's Cube groups.

proof:
It is conjectured that Egglepple's movements [closed circuits] exist between amplitudes on a cryptograph. These motifs - known as stews - are analogous to string tunings, and aid in the stereotypography of fibor [:== an automaton that is a unique and totally twistable ||f(u,u)=0|| crypto mesh (cluster) of links (L) which is subject to stewcing].


Corollary
Solving RC groups in terms of molecular dynamics at the natural base speed of femtoseconds is physically infeasible for a human, and must be done virtually. The STUBE is a virtual Rubik's Cube. The puzzle🧩, then, is to devise/train an algorithm ( =StewE) to solve or assemble any configuration state of the STUBE given the following budgetary constraints: less than 20 moves per solve (set spatial upperbound) within some event frequency of (1/370)d./// There are a total of 43,252,003,274,489,856,000 possible permutations of a Rubik's Cube. Measurements in attoseconds are not appropriate here since they can theoretically be faster than our combinatorial space.

STUBE™
virtual 3-cube for permucomps
Solve any topology in < 20 moves.

✓game

¶ --> Using stewdio.js to match Rubik's cubelets with fold structures so that outputs are batched + pushed for training.

Result: a tailored mobile browser-based/virtual 3d Rubik's Cube (3×3×3) which can be a demonstrable pipeline accelerator in drug design and macromolecular/peptide science for public benefit.[-You're welcome.]

Stewdio ↓

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¶Artificial intelligence (ai) works by transforming repos of multimodal parameters for machine learning (ml). Organic intelligence (oi -our 'superbrains🧠') works essentially by gene transfer. Both rely on neural nets. oi trumps ai here precisely because I'm not dependent on a large language model (llm), but permutation groups, instead. For this reason, the Rubik's Cube only requires a relatively small amount of algorithms (algs) for attention./// permucomputation complexity: P=BQP --> because the 🧠brain is a quantum computer.


¶On this site @uuelco.ME, Cube move notation is printed in the chat. Printing's really cumbersome on my end (I have to type it in move-by-move), but with automation (ie. me dictating moves to the API^[l]) ...I think you catch my drift; faster STUBE twisting leads to more intelligence and bigger compiles./// Web adage: the more posts/comments to a blog, the merrier because spiders (bots) are attracted to a site's indexed links for purposes of web crawling in order to build a better "web".

-ideation graphics of the Stewdio as a speedcube and chatbot-

/// Keep in mind that these images are just ideations (aren't they cool, though?). They exist to conceptualize how the STUBE's user could theoretically interface with panels that discuss relevant computational chemistry. In practice, this is basically speedcubing.
¶Some people have asked, "Well, why don't you just use ai to train all the models, and then there are your answers?". --In a sense, that's what is being done industrially. One of the issues with ai is that it can only be trained on uploaded datasets. As potent as it is, ai comes nowhere near the capacity of the human brain🧠 in terms of speed, scaling, or energy management. (psst! ai still hasn't reliably solved a Rubik's Cube in less than 20 moves^[n], which is the necessary threshold for finding optimal fold structures) Another question often asked is, "Why not just use off-the-shelf software^[2][v] built specifically for said science?". --Mainly because those products are bloated, making the learning curve too wide for beginners (our target market), ultimately lowering our contribution knowledge base. The Cube, on the otherhand, is based on very simple math, so it is the better option./// trivia: the Rubik's Cube is the world's bestselling toy.

lnq👨🏿‍🦱 demo STUBE solve with bionic arms (ai)

¶Solving the Cube requires a certain amount of ingenuity, regardless of the type of intelligence (articial vs. organic). 100M tokens (here token = second/data) worth of data should be enough for a human to creatively solve any scramble; I know this has to be true because the Rubik's Cube can be solved by a 3 year-old^[c] child.



¶The cubing community already has an extensive library of algs and solves that I'm going to apply to peptides for a new training stack. Automation enables me to stube [ie. put into a virtual speedcube and completely solve by mapping folding products to their 1 of 27 respective cubic blocks/cells (stewc --> stube)] each molecule with relative quickness. Compiled results (grouped by #hashtag before being fed to a neural network) may then be submitted to their respective academic journals and/or labs./// Notes: +I'm not a medical professional, but I anticipate plenty of follow-up questions to which I'll preface that any pharmaceutical or clinical discussion to be had should only come after solutions are posted. For now, this is an activity that I just do for myself as play therapy, with no further ambition. Even if strategies are adopted, residual scientific papers published, and a bunch of really smart people come to a consensus, it (as does any legally marketed medicine) will still need FDA approval.

+The 2024 Chemistry Nobel laureates won for their work on 'computational protein design'^[h]. What I'm doing here with stubing is moreso related to the 'protein folding problem'; resolving the dynamics of Levinthal's paradox^[l] exactly. Together, both halves constitute a breakthrough in drug discovery.

✓purpose

¶Biochem requires more robust paneling (for cluster analysis, notebooks, script creation, etc.) than simple cubing to run a full computation. But, data gathering-matching is a good start.

¶The Stewdio needs to be transpiled/code refactored into a javascript (stewdio.js) canvas^[d] so that functionality is automated. This step is crucial to increasing the maximal number of brute force attempts involved in online speedcubing (the superchat output results are archived to spreadsheets for ml #threading --congruent to a trainable ai model). --> what ships: code dump, executable

-ideation graphic (sample) of the Stewdio as a solved speedcube-

✓extracurricular

¶I'll then have enough of a personal energy budget (permuting peptides for me generally consumes an enormous amount of calories) moving forward to begin work on solving (I foremost care about the topologies, not so much the functions of) the following 9 molecules [each are related to Alzheimer's | Huntington's | Parkinson's disease(s)]:

Alzheimer's Disease (AD) is a progressive, neurodegenerative brain disorder that is the most common cause of dementia, primarily affecting memory, thinking skills, and eventually, the ability to perform basic daily tasks.
Clue/Tip: Specific strains of Desulfovibrio bacteria are likely to cause Parkinson's disease (ie. buildup of alpha-synuclein in the spinal cord and/or 🧠brain). Therefore, removing the bacteria from a person's environment/diet/gut should help prevent the disease.👍🏿
#AlzheimersDiseasesucks

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Huntington's disease (HD) is a hereditary neurodegenerative disorder that causes the progressive breakdown and death of nerve cells (neurons) in specific areas of the brain, particularly those involved in controlling voluntary movement, as well as cognitive and emotional functions. #HuntingtonsDiseasesucks

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Parkinson's disease (PD) is a chronic, progressive neurodegenerative disorder that primarily affects the dopamine-producing neurons in the spinal cord and/or pars compacta area of the brain called the substantia nigra. The hallmark of PD is the loss of these neurons, which leads to a deficit of dopamine, a neurotransmitter crucial for smooth, coordinated muscle movement. #ParkinsonsDiseasesucks

Clue/Tip: Specific strains of Desulfovibrio bacteria are likely to cause PD. Therefore, removing🧹 the bacteria from a person's environment/diet/gut should help prevent the disease.👍🏿

--------

-alpha-synuclein
¶As far as Parkinson's (PD) is concerned, aggregation of misfolded α-syn [PARK1] into Lewy bodies plays a role in neurotransmitter release and synaptic vesicle management. The misfolding causes lewy toxicity (ie. compromised DNA repair), resulting in cell (neuronal) death. If this spreads to other neurons, then you've got a progression of the disease (in the brain AND/OR the heart). Keep in mind that the brain really begins directly behind the retina (which is where clumps of the protein can intially be examined without the use of MRI).

¶The isoform of this synuclein that I will be tackling has 140 amino acids.
-STING
¶"STimulator of INterferon Genes" (acronym) is a signaling protein for detecting cytoplasmic DNA (cytoDNA). Endogenous cytoDNA can contribute to sterile inflammation (ie. no pathogens) from hyperactivation, leading to cancer (dysregular cell growth) and/or neurogeneration. <-- real nasty ish!
amino acid count: 379
-PINK1
¶PTEN-induced kinase 1 is important for maintaining mitochondrial health and quality control, as it targets damage/degradation/depolarization to the organelle (which supplies cells with their energy source). Without PINK1 properly functioning (from, say, genetic mutations), it can't recruit enough parkin from the cytoplasm to mediate dysfunctional mitochondria. Mutations of the gene lead to the death of dopaminergic neurons, causing Parkinson's.
amino acid count: 581
-huntingtin (Htt)
¶Huntingtin is essential to human life, as it is instrumental in longterm memory storage, and the axonal flow mechanisms (ie. organelle transport throughout the cell). It's a huge protein to begin with (3,144 amino acids), but is abnormally so in terms of the Huntington's Disease (HD) where the htt gene's DNA CAG trinucleotide is repeated a 36th time (1 more than the usual 10-35), leading to a mutant protein that then becomes fragmented and misfolds (the keyword in pathologies). These misfolds interfere with normal cellular+motor functions (those available in early development) that prove critical to personality, cognition, ambulation, and emotion.
-granulin (GRN or PGRN)
¶Primarily located within the cell's lysosome (the organelle responsible for catabolic degradation of macromolecules, namely proteins/enzymes and carbohydrates), progranulin has been implicated in both cell proliferation and cell inhibition.

In both PD and AD, low granulin levels have been shown to be pathological.
amino acid count: 593 (progranulin)
-SERPINF2
¶(Serpin Family F Member 2) The serpin proteins are protease ('worker bee' enzymes that break proteins down into even smaller peptides) inhibitors. SERPINF2's role is to inhibit plasmin, itself a enyzme for degrading (breadking down) fibrin (the main protein in blood clotting), thereby maintaining hemostasis.
amino acid count: 482
-GSTP1
¶(Glutathione S-transferase P1) An enzyme (meaning that it catalyzes) with a critical role in cellular detoxification at the hydrophilic level (phase II).

Single nucleotide polymorphisms lead to different (and varied) responses to exogenous compounds (eg. drugs), including glutathione metabolism. Applied to neuropathology, GSTP1 can be like an overprotective parent, prohibiting drugs from reacting with or binding to their intended target(s), thus chaperoning oxidative stress.
amino acid count: 209
-BIN1
¶Bridging Integrator 1 (aka Amphiphysin II) is tricky because of its various Jekyll-Hyde isoforms, which it assumes through splicing. It is involved primarily with muscle regulation (myo motility).

In at least one of its isoforms, BIN1 is known for being a tumor suppressor protein (helping prevent cells from growing and dividing too rapidly). That sounds good, but its other responsibility within cells is to kill them (programmed 'off-switch'). Now, couple that with neurons, and you could - depending on the isoform - get conditional myotonic atrophy, or neurofibrillary tangles which cause diseases like Alzheimer's (AD).
amino acid count: 409-593 (isoform-dependent)
-siglec-3 (CD33)
¶The siglec (sialic acid-binding immunoglobulin-like lectin) family of transmembrane glycoproteins (the 's' could just as easily be for 'sugar') regulates (cf. inhibits) immune cell function, particularly those responsible for causing inflammation in the peripheral nervous system.

Pathologically, polymorphic CD33 expresion in brain immune cells is linked to Alzheimer's.
amino acid count: 363

Solve the STUBE™

Win $$, 1-min 🏆comps
fastest solve = fewest moves:
🏅winner: 50%
2nd: 20% | 3rd: 10%

$ = chat w/ me -- In my comment box: leave some text, post a solve, or promote your business.

Step 1: Pay. After confirmation of payment on my end, I will retrieve your safe files and then post your ad or comment in the chat.

Step 2: In the chatbox, reply or enter: "#ad" along with either plain text, the image file (.jpg, .png, .gif) URL [example: #ad https://photos.google.com/u/#/imglink123], the YouTube video URL [example: #ad https://www.youtube.com/watch?v=VIDEO_ID], or a combination of all three (3). Click . ///Note: The image/video is the whole ad (this should already include things like a website/QR code/phone number). Example provided below.

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No refunds allowed.

Transactions are final. The entry is fair and very low ($1), so your risk is negligible. -Best regards.